20 years of

GUT EXPERIENCE

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We are dependent on our oral and gut microbes to perform many functions that are essential to our health. 

The oral and gastrointestinal tract microbiome constitute the bulk of the overall human microbial load.      The interconnected network of microorganisms present unique opportunities for advancing human health therapy.

The oral microbiota is an essential step understanding

  • the strategies of better oral health
  • the production of biofilm of the oral cavity

  • the intestinal barrier and production of mucin

  • a neutralization of pathogenic bacteria

  • the cell response and metabolism of substrates

  • interaction with immune response

  • anaerobic bacteria associated with periodontal diseases leading to halitosis

Saliva maintains a stable pH of 6.5 to 7.5, the preferred pH for most bacteria species. Saliva also keeps bacteria hydrated and acts as a medium to facilitate the transportation of nutrients to microorganisms.

The microbiota of the oral cavity, with more than 700 bacterial species, is one of the most densely populated anatomical sites within the human body.     

 

One that requires our attention.

 

A biological approach for an optimal oral microbiota that helps and prevents dental caries, gum damage and halitosis

with the right dietary and oral hygiene habits

  • 3 bacterial cultures

    • Lactobacillus salivarius

    • Bifidobacterium animalis ssp.lactis

    • Lactobacillus rhamnosus

  • Xylitol,

  • Blueberry flavor,

  • Vitamin C (25% of RDA),

  • Vitamin D3 (100% of RDA).

DentaSan® provides beneficial functions on

  • oral biofilm modulation and restoration
  • good bacteria colonization

  • pathogenic bacteria inhibitor effects

  • counteracts inflammation, tissue damage

  • helps controlling halitosis

  • building up healthy gums

  • prophylactic treatment of gum infection

  • regeneration after a dental treatment.

Why DentaSan® probiotic for oral health?

  • Prevention of oral dysbiosis 
  • Backed-up by world-class studies

  • User-friendly,

  • Directly under the tongue

  • No side effect.

  • No change of color of tooth enamel.

  • Refreshing taste.

  • A biological and alternative therapy.

Study Berwal V. et al 2017​ 

  • Streptoccocus salivarius, L. rhamnosus and L. reuteri showed a significant reduction in Streptococcus mutans

  • B. animalis ssp. lactis reduces the number of Streptococcus mutans in patients with dentures

Study Rosier Mahasneh et al. 2017

  • Lactobacillus sp. positively support periodontal conditions,

  • L. rhamnosus positively supports the immune response

  • B. animalis subsp. lactis ensures very good resistance to oral infections

  • Probiotic bacteria inhibit pathogenic agents (tooth decay and inflammation)

  • Lactobacilli have intra-oral significant health-promoting effects.

Study Rosier B. et al. 2018

  • Higher SIgA levels were isolated against Streptoccocus mutans in people who suffer less from caries.

  • Probiotic therapy approaches support the treatment of gingivitis and periodontitis.

Advanced human therapy. For an optimal gut microbiota.

 

Lactobact® BABY+

0 to 2 years

  • 3 selected bacterial cultures
    • Bifidobacterium bifidum 

    • Bifidobacterium breve 

    • Lactobacillus casei 

  • Builds up immunity 

  • Prevents colics

  • Supports constipation and bloating relief

  • Promotes balance during and after antibiotic intake.

  • Folic acid supports maternal tissue growth during pregnancy

  • ​To be stirred into the bottle or mushy food.

  • No activation time. A direct consumption is possible. 

  • They are protected from oxidation and moisture.

  • No refrigeration needed.

Lactobact® JUNIOR+

2 years to 8 years

  • 6 selected bacterial cultures

    • Bifidobacterium bifidum

    • Bifidobacterium breve

    • Bifidobacterium lactis

    • Lactobacillus casei

    • Lactobacillus plantarum

    • Streptococcus thermophilus

  • Restores intestinal flora

  • Relieves constipation

  • Folic acid (Vit B9) supports the immune system

  • Pantothenic acid (Vit B5) helps reduction of fatigue.

  • Direct consumption. 

  • No activation time needed.

  • To be stirred into drinks, food.

  • They are protected from oxidation and moisture.

  • No refrigeration needed.

Lactobact® PREMIUM

8 years+ children, teenagers, adults

  • ​9 selected probiotic strains

    • Bifidobacterium bifidum

    • Bifidobacterium breve

    • Bifidobacterium lactis

    • Bifidobacterium longum

    • Lactobacillus casei

    • Lactobacillus paracasei

    • Lactobacillus plantarum

    • Lactobacillus rhamnosus

    • Streptococcus thermophilus

  • Supports a normal fatty acid and carbohydrate metabolism

  • Contains zinc gluconate

  • Zinc supports the body's defenses

  • The cellulose capsules can be removed and the micro-encapsulated powder stirred into drinks and food. (The micro-encapsulated powder combined with an additional cellulose capsule offer double protection for patients having difficulty in swallowing capsules).

Most probiotics on the market do not really survive stomach and pancreas passage. 

Indeed, the use of a lyophilized powder does not offer a protection to the bacteria, and therefore get damaged.

Lactobact use Intelicaps® a new dimension to probiotic microencapsulation.

  • ​Intelicaps®, a new and patented technology, uses a very gentle extrusion process and a proprietary mix of biopolymers. 

  • The microcapsules are then very stable, capable to resist to increased heat, low pH, moisture and increased oxygen concentrations. 

  • Resistant to low pH values.

    • They resist to 80%+ at pH <2 after 2 hours when classic lyophilized probiotics achieve only less than 8%. 

    • They only open in the intestinal tract at a pH >6,5. ​​​

  • Resistant to elevated storage temperatures.

  • Very high survival rate of the bacterial cultures during the stomach and duodenum passage.

Compared to most probiotics, Lactobact® Intelicaps® selected SHIME® one of the few gut models to demonstrate the efficacy of the protection capability of the new microencapsulation.

The SHIME® model (Simulator of the  Human  Intestine  Microbial  Ecosystem) is the sole in vitro model that integrates the entire gastrointestinal transit into one system.

  • Unlike the large majority of gut models, the SHIME® mimics the entire gastrointestinal tract incorporating stomach, small intestine and different colon regions.

  • The SHIME® brings unique capabilities to study physicochemical, enzymatic and microbial parameters in the gastrointestinal tract in a controlled in vitro setting.

  • The SHIME® set-up leads to an accurate and relevant simulation of the targeted human host.

Typically, a SHIME® experiment consists of 4 stages:

 

  1. a stabilization period (2 weeks) to allow adaptation of the microbial community to the environmental conditions in the respective colon regions; 

  2. a basal period (2 weeks) in which the reactor is operated under nominal conditions and baseline parameters are measured; 

  3. a treatment period (2–4 weeks) where the effect of a specific treatment on the gastrointestinal microbial community is tested;

  4. a washout period (2 weeks) to determine how long the changes induced by the tested substance can still be measured in the absence of the substance itself. 

This is interesting to study for example digestibility of prebiotic substrates and its subsequent fermentability in the colon or the survival of pathogens or probiotics in the upper digestive tract before they reach the colon environment.

This approach has mainly been used to investigate the activity and stability of probiotics and prebiotics during gastrointestinal transfer, the microbial conversion of bioactive food components (e.g. phytoestrogens), the metabolism of pharmaceutical components, the efficacy of colonic targeted delivery systems and the conversion and biological (in)activation of food and/or ingested environmental contaminants.

30 years of accumulated Know-how

Since 1993

Unique scientifically validated dynamic model.

160 peer-reviewed scientific publications

Entire gastroentestinal transit

SHIME® simulates both the upper and lower GT 

- the upper (stomach, small intestine)

- the lower (ascending, transverse, descending) colon regions

SHIME® mimics the conditions in all colon regions 

  • ascending, 

  • transverse,

  • descending

Each pH condition 

SHIME® covers the pH variety and complexity.

 

the gastric compartment works at a fixed pH of 2.0

the small intestine compartment typically operates at slightly acidic to neutral conditions

the pH of the colon compartments is controlled between

  • 5.6 - 5.9 in the ascending

  • 6.1 - 6.4 in the transverse

  • 6.6 - 6.9 in the descending colon. 

Human target groups

SHIME® brings the possibility of simulating the microbiome from different human target groups e.g 

  • adult vs. infant,

  • healthy vs. diseased 

What does intestinal flora mean?

Intestinal flora is the term for a multiplicity of bacteria which live in our intestine. They are on the mucus layer lining the intestine. The bacteria in the intestine bring a weight of about 1-2 kgs on the scales. Their tasks are vital to the body. For example, they are involved in enzyme and vitamin formation and in the breakdown of plant compounds that we otherwise would not digest. In addition, our intestinal flora communicates with the immune system and supports the formation of anti-inflammatory messengers. The protection against pathogens also comes from the intestinal flora .

What is a disturbed intestinal flora?

A disturbed intestinal flora is called dysbiosis in medical parlance. This means that pathogenic bacteria in the intestine could multiply many times. This leads to an altered bacterial colonization. The consequences of a disturbed intestinal flora can not only be diarrhoea, constipation and flatulence, but also inflammatory diseases occur. If it comes to a dysbiosis, you can with a balanced, high-fiber diet, exercise and with probiotics preparations to rebuild the intestinal flora.

What can an intestinal flora be disturbed?

A disturbance of the intestinal flora can come about through various causes. An unbalanced diet high in fat, sugar, and low fiber negatively affects the intestinal flora composition. Also, the factor of movement plays a major role for a balanced healthy bacterial composition in the intestine. Antibiotics are a common problem. Antibiotics have to be taken for some diseases, but unfortunately they not only kill pathogenic bacteria but also kill our healthy intestinal bacteria. Babies often suffer from disturbed intestinal flora if they are born by caesarean section or are not breastfed.

WHAT DOES PROBIOTIC INTESTINAL BACTERIA MEAN?

"Probiotics are living microorganisms that, when consumed in adequate numbers, have a health effect on the host," is the WHO / FAO definition of probiotic intestinal bacteria since 2001. This means that probiotic gut bacteria must meet specific requirements. First and foremost, it is important that the bacteria survive the gastric and bile acids without damage. Because unprotected strains of bacteria can lose their viability within a very short time and thus become ineffective. The products should also be present in high concentrations. 

WHICH PROBIOTIC INTESTINAL BACTERIA ARE INSIDE?

There are a variety of probiotic bacterial strains with clinical evidence in the gastrointestinal tract. In medical use, the following probiotic species are predominantly used: lactobacilli , bifidobacteria , Enterococcus faecium and Escherichia coli. A combination of selected probiotic intestinal bacteria in high concentration ensures the desired health effect.

WHEN DO YOU USE PROBIOTIC INTESTINAL BACTERIA?

There is now a wealth of clinical study material on the administration of probiotic intestinal bacteria . Probiotic intestinal bacteria are used at any age. In babies born as cesarean birth or not breastfed, it was found that the intestinal flora is different in composition compared to vaginal birth and nursing children. When occurring three-month colic also like probiotics are used. Older children are often affected by asthma, allergies and atopic dermatitis or antibiotics cause a shift in the intestinal flora . Meanwhile, diseases of the nervous system are increasingly in the focus of the researchers, in which a maloccupation of the intestinal flora seems to play a role